Nutraferon TAPENTOL 50MG Tablets

Name: Nutraferon TAPENTOL 50mg ER Tablet: Tapentadol Titration Care
SKU: NF00078
Price: 380.00 INR
Availability: InStock

Nutraferon TAPENTOL 50MG Tablets

SKU: NF00078 Category Pain Management

Manufacturer/Marketer

NUTRAFERON PVT LTD

Consume Type

Oral

Return Policy

NOT RETURNABLE

Product Discription

Nutraferon TAPENTOL 50 mg for Initiation, Titration & Maintenance of Severe Chronic & Neuropathic Pain

₹380.00

Nutraferon TAPENTOL 50MG Tablets – Overview

Nutraferon TAPENTOL 50 mg Extended-Release (ER) Tablet provides the foundational 50 mg initiation and titration strength of Tapentadol (as Tapentadol Hydrochloride) in a 12-hour controlled-release hydrophilic matrix. Combining mu-opioid receptor (MOR) agonism with noradrenaline reuptake inhibition (NRI) in a single molecule, it is designed for round-the-clock management of severe chronic nociceptive and neuropathic pain when non-opioid alternatives are inadequate.

Explore our other Nutraferon healthcare products to learn more about our product range. You can also visit our healthcare website for additional information.

Clinical Highlights

Synergistic Dual MOR + NRI Pharmacology: Moderates ascending nociceptive transmission via central mu-opioid receptors while inhibiting presynaptic noradrenaline reuptake (NRI) to amplify descending spinal α2-adrenergic pain inhibition.
Non-CYP2D6 Phase II Glucuronidation Clearance: Intrinsically active parent molecule cleared ~70% via hepatic Phase II glucuronidation (UGT1A9/UGT2B7) without requiring CYP2D6 metabolic activation, avoiding genetic poor/ultra-rapid metabolizer variability.

Key Benefits

Standard 50 mg ER Initiation & Titration Strength: Recommended starting dose (50 mg ER twice daily) for opioid-naïve patients initiating round-the-clock Tapentadol ER therapy, allowing safe upward titration in 50 mg BID increments every 3 days.
Dual Nociceptive & Neuropathic Pain Coverage: Addresses both structural osteoarticular/visceral pain and maladaptive neuropathic nerve pain.
Effective in Painful Diabetic Peripheral Neuropathy (DPN): Relieves chronic burning, shooting, and hyperalgesic nerve pain in diabetes.
Improved Gastrointestinal Tolerability: Lower incidence of nausea, vomiting, and constipation compared to equianalgesic pure mu-opioid agonists.

Directions of Use & Safety Information

Dosage & Titration Schedule: Take strictly as prescribed by your pain specialist or physician—typically initiated at one 50 mg ER tablet twice daily (approximately every 12 hours), with or without food, and titrated by 50 mg twice daily no more frequently than every 3 days to the effective maintenance dose (100 mg to 250 mg twice daily; max 500 mg/day).
Administration (Do Not Crush or Split): Swallow the 50 mg ER tablet whole with a full glass of water. Never chew, crush, split, or dissolve the tablet, as breaking the controlled-release matrix causes rapid dose-dumping and potentially fatal respiratory depression.
Renal & Hepatic Impairment Restrictions: Not recommended in severe renal impairment (CrCl < 30 mL/min) or severe hepatic impairment (Child-Pugh Class C). In moderate hepatic impairment (Child-Pugh Class B), initiate at one 50 mg ER tablet once every 24 hours (maximum 100 mg/24 hours).

FAQs

When is the 50 mg strength of Nutraferon TAPENTOL ER prescribed? +

Can Nutraferon TAPENTOL 50 mg ER be used on an "as-needed" basis for sudden acute pain? +

Why is it dangerous to chew, crush, or split the 50 mg ER tablet? +

Can this medication be stopped abruptly once chronic pain is controlled? +

Which medications and substances must be avoided while taking Nutraferon TAPENTOL 50 mg ER? +

Disclaimer

Controlled Prescription Only Medicine (POM). Boxed warnings apply for addiction, abuse, and misuse; life-threatening respiratory depression; accidental pediatric ingestion; neonatal opioid withdrawal syndrome; and concomitant use with CNS depressants. Contraindicated in severe respiratory depression, acute/severe bronchial asthma, paralytic ileus, and MAOI use within 14 days. Store locked below 25°C.

Description

Nutraferon TAPENTOL 50MG Tablets – Overview

Explore our other Nutraferon healthcare products to learn more about our product range. You can also visit our healthcare website for additional information.

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Our Clients Reviews

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   Atchuta Rao Kavuri 
 
 
 
 Trustindex verifies that the original source of the review is Google.  good product
  
 
 
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   Satish R 
 
 
 
 Trustindex verifies that the original source of the review is Google.  Excellent quality full range of products at reasonable price.
  
 
 
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   Srujan Raga 
 
 
 
 Trustindex verifies that the original source of the review is Google.  Good products and Good customer care and perfect and in time delivery for every clients .
Pan India delivery 🚚 and Amazon and Tata 1 Mg products are available   💊 💉
#Nutraferon Pvt LTD#Hyderabad #Telangana #India
  
 
 
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   MAHERUNNISA BEGUM 
 
 
 
 Trustindex verifies that the original source of the review is Google.  Good
  
 
 
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   Roronoa Zoro 
 
 
 
 Trustindex verifies that the original source of the review is Google.  Nice product with good ingredients.
  
 
 
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   Vijay Chowdary 
 
 
 
 Trustindex verifies that the original source of the review is Google.  Good working
  
 
 
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   joynikhil 
 
 
 
 Trustindex verifies that the original source of the review is Google.  Good
  
 
 
  
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Nutraferon TAPENTOL 50MG Tablets

Nutraferon TAPENTOL 50MG Tablets

Product Discription

Nutraferon TAPENTOL 50MG Tablets – Overview

Clinical Highlights

Key Benefits

Directions of Use & Safety Information

FAQs

Disclaimer

Reviews

Description

Nutraferon TAPENTOL 50MG Tablets – Overview

Reviews

Our Clients Reviews

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