Nutraferon TRADO Tablets

Paracetamol acts rapidly to relieve pain early, while Tramadol acts on both mu-opioid receptors and spinal serotonin/noradrenaline pathways for longer-lasting relief—achieving stronger pain control with lower side effects than high doses of either drug alone.

Each tablet contains 325 mg of Paracetamol. Taking extra over-the-counter Paracetamol tablets or cold/flu powders can exceed the safe daily Paracetamol limit and cause acute, potentially fatal liver failure.

Because the liver enzyme CYP2D6 converts Tramadol into its potent opioid metabolite (M1), individuals who are genetic CYP2D6 Ultra-Rapid Metabolizers produce dangerously high opioid levels that can cause fatal respiratory depression. Therefore, Tramadol is STRICTLY CONTRAINDICATED in all children younger than 12 years of age, in adolescents younger than 18 years following tonsillectomy and/or adenoidectomy, and in breastfeeding mothers (M1 passes into breast milk and can cause fatal neonatal sedation/respiratory arrest)

1) Seizure Risk & Serotonin Syndrome: Tramadol lowers the seizure threshold and increases central serotonin; combining it with SSRIs, SNRIs, Tricyclic Antidepressants, Triptans, MAOIs (contraindicated within 14 days), Linezolid, or Bupropion can trigger generalized seizures or life-threatening Serotonin Syndrome. 2) CYP2D6 Inhibitors (Fluoxetine, Paroxetine, Quinidine): Block conversion of Tramadol to active M1, reducing pain relief while raising seizure risk. 3) Ondansetron (`ONDON`): Can partially antagonize Tramadol's spinal 5-HT analgesic effect. 4) Warfarin: Tramadol and Paracetamol can elevate INR.

Yes. Regulatory safety alerts note that Tramadol can rarely induce severe hypoglycemia (especially in elderly or diabetic patients within the first 30 days) and SIADH-induced hyponatremia.