Nutraferon ADEMO Tablets

Intrahepatic cholestasis occurs when bile flow slows or stalls within the microscopic bile ducts of the liver, causing bile acids and bilirubin to accumulate in the blood. Nutraferon ADEMO supplies SAMe, which restores liver cell membrane fluidity and stimulates bile salt export pumps to normalize bile flow and relieve symptoms like itching.

SAMe is a physiological molecule synthesized from the amino acid methionine and ATP in the liver. It acts as an essential methyl donor and precursor for glutathione, protecting hepatocytes from oxidative stress and inflammatory damage.

SAMe is best absorbed on an empty stomach, 30 to 60 minutes before meals. Because SAMe can mildly increase alertness in some individuals, divided doses are typically scheduled before breakfast and lunch rather than right before bedtime.

Always consult your prescribing physician or pharmacist before combining Nutraferon ADEMO with other medications. SAMe increases central serotonergic turnover and must not be combined with selective serotonin reuptake inhibitors (SSRIs), SNRIs, tricyclic antidepressants, MAOIs, tramadol, or dextromethorphan without strict specialist oversight due to the risk of serotonin syndrome.

Symptomatic improvements in cholestatic itching and fatigue may begin within 1 to 3 weeks, while biochemical normalization of liver enzymes (ALT, AST, ALP, GGT, and bilirubin) typically requires several weeks to months of consistent therapy monitored via routine liver function tests.